Endocrine Abstracts

Introduction: Congenital hyperinsulinism (CHI), is the most frequent cause of persistent hypoglycemia in infancy. Mutations in the ABCC8 gene are responsible for 40–50% of CHI cases. Its management can be extremely complicated. The main goal of the treatment is to maintain normoglycemia, since hypoglycemia during infancy can have severe neurological consequences. Herein, we report 8 year follow up of twin patients who were diagnosed with CHI at neonatal period due to SUR1...

Much controversy persists over aggressiveness of oncocytic thyroid carcinoma (OTC) and its optimal treatment. The study purpose was to determine prognostic factors for persistent or recurrent disease (PRD) and discuss therapeutic directions.We reviewed the medical records of 81 consecutive patients with OTC among a total of 1729 (4.7%) epithelial thyroid cancers, operated from 1983 to 2003 in our center. Follow-up information was updated. Age ranged from...